The National Library of Medicine published the results of a comparative study, which found Naltrexone implants to be effective at reducing mortality rates for people who are addicted to opioids. The Naltrexone implant is becoming a popular method of treatment for those suffering from an addiction to opiates because it provides long-term relief, unlike the more commonly prescribed oral naloxone solution which requires the user to responsibly take the medication on a daily basis—more often leading to relapse versus its counterpart.

Comparative studies have also shown that naltrexone is similar to buprenorphine in terms of safety and effectiveness for treating opioid addiction, but the implanted version of Naltrexone ultimately proved to lower the likelihood of an overdose occurring (both during and following the patient receiving the Naltrexone implant). As a result, there is increasing interest in the use of implantable naltrexone as a new treatment for opiate dependence.

Similar articles have studied the safety profile of naltrexone implant therapy (NIT), showing the treatment correlates with previously presented mortality data and adverse events. Conclusively, the data from these studies prove that NIT economizes treatment resources without compromising safety concerns.